Vitamin D (Colecalciferol/Cholecalciferol/Vitamin D3)

Colecalciferol: A Fat-Soluble Nutrient with Health Benefits

Vitamin D3, also known as colecalciferol, is a vital fat-soluble nutrient that is essential for human health. It is produced in the skin when exposed to sunlight and can also be found in certain foods such as fatty fish and liver. Despite its nickname as "the sunshine vitamin," many people do not get enough vitamin D from sunlight alone and must obtain it from other sources such as nutritional supplements or certain foods. However, there are not many foods that contain high amounts of vitamin D, leading to widespread deficiency. This deficiency is especially prevalent in young adults, with 32% of those in Australia being deficient. Researchers worldwide have referred to vitamin D deficiency as an "invisible epidemic."

Vitamin D3 plays a crucial role in bone health by helping the body absorb calcium and phosphorus from the diet. It is also involved in immune system function and has been shown to have a protective effect against various health conditions. While the optimal daily amount of vitamin D and its potential to cure diseases remains a subject of debate, there is a strong link between vitamin D deficiency and poor health outcomes.

In order to become active, vitamin D must undergo two processes called hydroxylations in the body. These processes convert vitamin D, which is biologically inactive when obtained from sun exposure, food, or supplements, into its active forms. The first hydroxylation occurs in the liver and converts vitamin D into 25-hydroxyvitamin D, also known as "calcidiol." The second hydroxylation, which primarily occurs in the kidney, produces the active form of vitamin D called 1,25-dihydroxyvitamin D, also known as "calcitriol." When calcitriol binds to the vitamin D receptor (VDR) found in nearly every cell in the body, it can influence gene expression and alter cellular behavior, regulating various physiological processes in the body.

Natural dietary sources of vitamin D3

There are a few dietary sources of vitamin D3, including:

Fatty fish: Fatty fish such as salmon, mackerel, and sardines are excellent sources of vitamin D3. A 100-gram serving of cooked salmon provides about 447 IU of vitamin D3, while the same serving of mackerel provides around 388 IU.
Cold liver oil: Cod liver oil is a very rich source of vitamin D3, with a single tablespoon (15 ml) providing over 1,360 IU.
Egg yolks: Egg yolks contain small amounts of vitamin D3, with one large egg yolk providing about 41 IU.
Cheese: Cheese can be a good source of vitamin D3, with one ounce (28 grams) of cheddar cheese providing around 114 IU.
Mushrooms: Wild grown mushrooms that have been exposed to UV light can also be a source of vitamin D2, D4 and even some shiitake mushrooms contain D3. A 3.5-ounce (100-gram) serving of these mushrooms can provide around 2,000 IU of vitamin D.

It is important to note that the amount of vitamin D3 in an animal's tissues can be influenced by its diet and can vary depending on factors such as the specific type of food, whether it's farmed or wild, the way it is prepared, and the specific brand.

Exposure to sunlight

Vitamin D is a hormone (secosteroid) that is produced when skin is exposed to sunlight. When UVB radiation with a wavelength of around 290-320 nanometers hits uncovered skin, it converts a compound called 7-dehydrocholesterol into previtamin D3, which is then converted into vitamin D3. Many factors can affect the amount of vitamin D that is produced, including the season, time of day, length of day, cloud cover, smog, skin melanin content, and the use of sunscreen. Fair-skinned individuals and those who are younger are more efficient at converting sunshine into vitamin D than those who are darker-skinned and over 70 years old. Additionally, personal factors such as genetic predisposition, sex, age, and dietary habits also play a role in an individual's response to vitamin D. According to a 2017 study, vitamin D deficiency is common among shift workers, healthcare workers, and indoor workers, likely due to differences in lifestyle factors such as sunlight exposure.

It is difficult to give precise guidelines for how much sun exposure is needed to maintain adequate vitamin D levels, but some experts suggest that 5-30 minutes of sun exposure, especially between 10 a.m. and 4 p.m., either daily or at least twice a week, to the face, arms, hands, and legs without sunscreen, may be sufficient. However, it is important to protect the skin from UV radiation, as it is a carcinogen and the leading cause of skin cancer. Sunscreen with an SPF of 15 or higher should be used when people are exposed to the sun to reduce the risk of skin cancer, although it should be noted that sunscreens with an SPF of 8 or higher may block UV rays that produce vitamin D.

The role of colecalciferol in bone health

Vitamin D is essential for maintaining healthy bones, as it helps to promote the absorption of calcium and phosphate from the intestine and regulate their metabolism. This is important because calcium and phosphate are essential for normal bone mineralisation. In cases of vitamin D deficiency, the body has been shown to absorb less than half the normal amount of calcium and crucially may compensate by activating the release of a hormone that mobilises calcium and phosphate from the bones, leading to decreased bone density and an increased risk of osteoporosis. This can result in thin, brittle, or misshapen bones, and can cause conditions such as rickets in children and osteomalacia in adults.

Adequate vitamin D levels are also important for preventing conditions like hypocalcemic tetany (muscle spasms and cramps caused by low calcium levels) and promoting bone growth and remodeling by osteoblasts and osteoclasts. When combined with calcium, vitamin D can also help to protect older adults from osteoporosis, a condition characterized by weak and brittle bones. This is often caused by low calcium intake, but inadequate intake of vitamin D can also contribute to osteoporosis by reducing calcium absorption.

A systematic review of 41 randomized controlled trials found that vitamin D3 supplementation improved bone mineral density and reduced the risk of fractures in older adults. Another study found that vitamin D3 supplementation improved bone density in postmenopausal women.

The benefits of colecalciferol for cardiovascular health

Vitamin D3 has been shown to have a protective effect on cardiovascular health. This is likely due to its role in regulating the renin-angiotensin-aldosterone system (which helps regulate blood pressure), vascular cell growth, and inflammatory and fibrotic pathways. Vitamin D deficiency has been associated with vascular dysfunction, arterial stiffening, left ventricular hypertrophy, and hyperlipidemia.

Observational studies have shown that higher levels of vitamin D, as measured by serum 25(OH)D levels, are linked to a lower risk of cardiovascular disease (CVD) incidence and mortality. A meta-analysis of 34 studies involving 180,667 participants found that higher levels of serum 25(OH)D were associated with a lower risk of CVD events and mortality. There is also evidence that vitamin D supplementation may have a positive impact on cholesterol and blood pressure, two major CVD risk factors. Genetic studies have suggested that a low vitamin D status may increase the risk of hypertension and CVD.

The role of vitamin D in depression

Depression is a common and disabling mental illness that affects people of all ages, genders, and races worldwide. In 2015, it affected 4.4% of the global population. Depression is associated with increased morbidity and mortality, as it increases the risk for stroke, cardiovascular events, and suicide, as well as lifestyle-related disorders such as diabetes and hypertension.

There is a well-established association between vitamin D deficiency and depressive disorders, as demonstrated by numerous studies. Vitamin D plays a role in various brain functions and its receptors are found on neurons and glia in certain areas of the brain that may be linked to the development of depression. Vitamin D may help regulate mood and reduce the risk of depression.

A systematic review and meta-analysis of 14 observational studies involving a total of 31,424 adults (mean ages ranging from 27.5 to 77 years) found a link between low levels of 25(OH)D and depression. A review of 7,534 people found that those who received vitamin D supplements while experiencing negative emotions saw an improvement in their symptoms. Supplementation with vitamin D may be particularly helpful for individuals with depression who also have a deficiency in the vitamin. Another study found that low vitamin D levels are a risk factor for more severe symptoms of fibromyalgia, as well as anxiety and depression. A study from the Netherlands found that those living with depression had 14% lower circulating concentrations of vitamin D (25-hydroxyvitamin D, a form of vitamin D) than those not diagnosed with depression.

The role of colecalciferol in immune system function

It is important to avoid severe vitamin D deficiency in order to maintain immune health. Low levels of vitamin D may be associated with an increased risk of infections, particularly colds and flus, and autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, and inflammatory bowel disease. Vitamin D3 has been shown to improve immune response in various conditions, and studies have found that vitamin D3 supplementation can reduce the incidence of respiratory tract infections in older adults.

Vitamin D enhances the activity of antimicrobial peptides (AMPs), which are found in immune cells and on mucosal surfaces and play a key role in defending the body against bacterial and viral infections. Adequate vitamin D levels are necessary for optimal immune function, and deficiency in this nutrient has been linked to an increased risk of respiratory and other infections. In vitro evidence supports the role of vitamin D in immune regulation and the effects of vitamin D metabolites on immune cells. Both animal and human studies have also demonstrated a relationship between low vitamin D levels and negative immune outcomes.

While clinical trials of vitamin D supplementation have had mixed results, the specific form, dose, and frequency of administration may be important factors to consider. Using vitamin D in a preventive setting may also be key to its effectiveness in improving immune health and reducing the risk of autoimmune diseases.

The potential of colecalciferol in cancer prevention

Vitamin D may have a variety of effects that could inhibit the development of cancer, such as promoting cell differentiation, inhibiting metastasis, and exhibiting anti-inflammatory, immunomodulatory, proapoptotic, and antiangiogenic effects. Observational studies have found that vitamin D is associated with a reduced risk of certain types of cancer.

In a meta-analysis of 16 prospective cohort studies involving 137,567 participants, a 50 nmol/L increase in vitamin D levels was linked to an 11% decrease in overall cancer incidence and a 24% reduction in cancer mortality among women. Another meta-analysis of clinical trials found that vitamin D supplementation reduced cancer mortality rates by 12-13%. The largest clinical trial, called VITAL, which included 25,871 men and women with no history of cancer, found that vitamin D supplementation did not significantly affect the incidence of breast, prostate, or colorectal cancer, but did reduce the risk of cancer in normal-weight participants. Some studies have also linked vitamin D to a reduced risk of specific types of cancer, such as breast, colorectal, lung, pancreatic, and prostate cancer.

Synergistic role of colecalciferol and vitamins A, K, K2 and magnesium

Studies have shown that vitamin D works synergistically with other vitamins and minerals to support overall health. For example, magnesium, a mineral that is involved in over 300 enzymatic reactions in the body and is essential for the proper function of the immune system, muscles, and bones, helps activate vitamin D and may have a synergistic effect on bone health and immune function when taken with vitamin D. Magnesium is required for the binding of 25(OH)D to the vitamin D binding protein (VDP), which enables circulation throughout the bloodstream and delivery to various tissues throughout the body. Additionally, Magnesium is a vital component in the conversion of 25(OH)D to the active 1,25(OH)2D hormone form. Both of these mechanisms are crucial in determining an individual's vitamin D status.

Vitamin K, a fat-soluble vitamin that is necessary for the synthesis of proteins involved in blood clotting and bone metabolism, has a synergistic effect on bone health when taken with vitamin D. Vitamin K2, a subtype of vitamin K found in fermented foods, has been shown to support cardiovascular and bone health. Vitamin D, specifically D3, plays a critical role in calcium homeostasis by increasing the intestinal absorption of calcium and phosphorus, and by promoting the renal reabsorption of calcium. Vitamin K1 and K2, on the other hand, are essential for the carboxylation of specific matrix Gla-proteins (MGP) and osteocalcin, proteins that are responsible for maintaining the structural integrity of the bones and preventing calcification in the soft tissues. The carboxylation process activated by vitamin K2, converts these proteins into their biologically active form. Together, vitamin D and K work in a synergistic manner to promote healthy bone mineralization and cardiovascular health.

Vitamin D and vitamin A also have a synergistic relationship in the body. Vitamin D is essential for the proper functioning of the immune system and for maintaining healthy bones, while vitamin A plays a critical role in vision, immune function, and cell growth and differentiation. Vitamin D plays a role in the regulation of vitamin A levels by controlling the expression of genes involved in vitamin A metabolism. When vitamin D levels are low, the expression of certain genes that are responsible for the conversion of beta-carotene to retinol (the active form of vitamin A) are suppressed. This can lead to a deficiency in vitamin A, which can have negative effects on vision, immune function, and skin health.

On the other hand, Vitamin A is also important for maintaining healthy levels of vitamin D. Retinoic acid, the active form of vitamin A, is essential for the proper functioning of the vitamin D receptor, which is responsible for the regulation of vitamin D metabolism. When retinoic acid levels are low, vitamin D metabolism is impaired, which can lead to a deficiency in vitamin D and the development of health problems such as osteoporosis and rickets.

Nutrients work in synergy to promote optimal health and prevent deficiencies in other nutrients. When an individual becomes insufficient or deficient in one, it can have a cascading effect on overall health, potentially leading to temporary symptoms, developmental issues, permanent symptoms, accelerated aging, and even premature death. It is essential to ensure adequate intake of all essential nutrients to maintain optimal health and prevent these negative outcomes.

What are the symptoms of vitamin D deficiency?

Vitamin D plays a critical role in maintaining strong bones and teeth, as well as supporting a robust immune system. Testing for deficiency and insufficiency in vitamin D can be done through measuring total serum 25-hydroxyvitamin D (or 25(OH)D) levels. A deficiency in vitamin D can lead to various health issues, including symptoms such as:

Fatigue and tiredness: Vitamin D plays a role in energy metabolism, so a deficiency can cause feelings of fatigue and tiredness.
Muscle weakness: Vitamin D is necessary for muscle function, so a deficiency can cause muscle weakness and a general feeling of malaise.
Bone pain: Vitamin D is important for bone health, so a deficiency can cause bone pain and an increased risk of fractures.
Impaired wound healing: Vitamin D is necessary for the healing process, so a deficiency can cause wounds to heal slowly.
Depression: Some research suggests that low levels of vitamin D may be associated with an increased risk of depression.
Hair loss: A deficiency in vitamin D can cause hair loss.
Dry skin: Vitamin D plays a role in maintaining healthy skin, so a deficiency can cause dry, flaky skin.

If you are experiencing symptoms associated with a deficiency in vitamin D, it is imperative to consult a health professional. They will be able to accurately diagnose the cause of your symptoms and recommend appropriate treatment options. It is worth noting that, according to clinical data, individuals who have more severe deficiencies or insufficiencies typically respond better to supplementation.

What are the potential side effects of taking vitamin D3 supplements?

Vitamin D3 supplements are generally well tolerated and have a low risk of side effects when taken in recommended amounts. However, taking excessive amounts of vitamin D3 can cause side effects, including:

Nausea and vomiting: Consuming large amounts of vitamin D3 can cause digestive symptoms, such as nausea and vomiting.
Constipation: Vitamin D3 supplements may cause constipation in some people.
Weakness: Large amounts of vitamin D3 may cause weakness and fatigue.
Loss of appetite: Some people may experience a loss of appetite after taking high doses of vitamin D3.
Weight loss: Consuming large amounts of vitamin D3 may cause weight loss.
Increased risk of kidney stones: Some research suggests that taking high doses of vitamin D3 may increase the risk of developing kidney stones. However, more research is needed to fully understand this relationship.
High blood calcium levels: Excessive amounts of vitamin D3 can cause high levels of calcium in the blood, which can lead to serious health problems, such as kidney damage and heart problems.

It is important to note that these side effects are typically associated with taking large amounts of vitamin D3, well above the recommended daily intake. It is important to speak with a health professional before taking vitamin D3 supplements to ensure that you are taking the appropriate amount.

Vitamin D3 supplements are generally safe when taken in recommended amounts. However, as with any supplement, it is important to speak with a health professional before starting to ensure that they are safe and appropriate for you.

Can vitamin D3 supplements interact with other medications or supplements?

Yes, vitamin D3 supplements can interact with certain medications and supplements. Some medications and supplements that may interact with vitamin D3 include:

Calcium supplements: Vitamin D3 helps the body absorb calcium. Taking vitamin D3 supplements along with calcium supplements may increase the risk of high levels of calcium in the blood.
Thiazide diuretics: These medications, which are used to treat high blood pressure, can reduce the absorption of vitamin D3. Taking vitamin D3 supplements along with thiazide diuretics may increase the risk of vitamin D3 deficiency.
Cholestyramine: This medication, which is used to lower cholesterol levels, can interfere with the absorption of vitamin D3. Taking vitamin D3 supplements along with cholestyramine may increase the risk of vitamin D3 deficiency.
Other supplements: Some supplements, such as large doses of iron, may interfere with the absorption of vitamin D3. It is important to speak with a health professional about potential interactions between vitamin D3 and any other supplements you are taking.

It is important to speak with a health professional before taking vitamin D3 supplements to ensure that they are safe and appropriate for you. They can help you understand any potential interactions with other medications or supplements you are taking.

Is it safe to take vitamin D3 supplements if I have a particular health condition?

Vitamin D3 supplements are generally safe and well tolerated when taken in recommended amounts. However, if you have a particular health condition, it is important to speak with a health professional before taking vitamin D3 supplements to ensure that they are safe and appropriate for you. Some conditions that may be affected by vitamin D3 supplements include:

Kidney disease: If you have kidney disease, your body may have difficulty processing vitamin D3. This can lead to an accumulation of the nutrient in the body and potentially cause side effects. It is important to speak with a health professional about the appropriate amount of vitamin D3 to take if you have kidney disease.
High blood pressure: Some research suggests that high doses of vitamin D3 may increase the risk of high blood pressure. It is important to speak with a health professional about the appropriate amount of vitamin D3 to take if you have high blood pressure.
Diabetes: Vitamin D3 may affect blood sugar levels in people with diabetes. It is important to speak with a health professional about the appropriate amount of vitamin D3 to take if you have diabetes.
Medications: Vitamin D3 supplements may interact with certain medications, such as thiazide diuretics and cholestyramine. It is important to speak with a health professional about potential interactions between vitamin D3 and any medications you are taking.

It is always important to speak with a health professional before starting any new supplement to ensure that it is safe and appropriate for you. They can help you understand any potential risks or interactions with your specific health condition and any medications or supplements you are taking.

Conclusion

Colecalciferol, also known as vitamin D3, is a fat-soluble vitamin that is essential for human health. It plays a critical role in bone health and is involved in immune system function. It has also been shown to have a protective effect against cardiovascular disease and certain types of cancer.

While sun exposure for vitamin D3 is important for maintaining adequate levels in the body, it is possible to obtain this nutrient with vitamin supplements. However, the best way to get the essential nutrients your body needs is to eat a variety of whole, unprocessed, fruits, vegetables, nuts, seeds, and other plant-based foods. Along with sun exposure, these types of food ensure that you are getting a wide range of nutrients, and should not be replaced by vitamin and mineral supplements alone.

References and further reading

“Office of Dietary Supplements, National Institutes of Health - Vitamin D,” n.d. https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/.
The Nutrition Source, Harvard School of Public Health. “Vitamin D,” November 14, 2022. https://www.hsph.harvard.edu/nutritionsource/vitamin-d/.
Mayo Clinic. “Vitamin D,” February 9, 2021. https://www.mayoclinic.org/drugs-supplements-vitamin-d/art-20363792.
Ware, Megan Rdn. “What Are the Health Benefits of Vitamin D?,” January 5, 2023. https://www.medicalnewstoday.com/articles/161618.
Devje, Shahzadi R. “Vitamin D Benefits.” Healthline, January 14, 2022. https://www.healthline.com/health/food-nutrition/benefits-vitamin-d.
Bischoff-Ferrari, H. A., et al. (2009). Effect of vitamin D on falls: a meta-analysis. JAMA, 291(16), 1999-2006.
Wang, S. (2009). Epidemiology of vitamin D in health and disease. Nutrition Research Reviews, 22(2), 188-203. doi:10.1017/S0954422409990151.
Ilahi M, Armas LA, Heaney RP. Pharmacokinetics of a single, large dose of cholecalciferol. Am J Clin Nutr. 2008 Mar;87(3):688-91. doi: 10.1093/ajcn/87.3.688. PMID: 18326608.
Mohammad Hassan Murad, Khalid B. Elamin, Nisrin O. Abu Elnour, Mohamed B. Elamin, Aziz A. Alkatib, Mitra M. Fatourechi, Jaime P. Almandoz, Rebecca J. Mullan, Melanie A. Lane, Hau Liu, Patricia J. Erwin, Donald D. Hensrud, Victor M. Montori, The Effect of Vitamin D on Falls: A Systematic Review and Meta-Analysis, The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 10, 1 October 2011, Pages 2997–3006, https://doi.org/10.1210/jc.2011-1193.
Shuler FD, Schlierf T, Wingate, M. Preventing falls with vitamin D. West Virginia Medical Journal. May/June 2014;110(3):10-12.
Horton-French, K., Dunlop, E., Lucas, R.M. et al. Prevalence and predictors of vitamin D deficiency in a nationally representative sample of Australian adolescents and young adults. Eur J Clin Nutr 75, 1627–1636 (2021). https://doi.org/10.1038/s41430-021-00880-y. Epub 2021 Mar 1. PMID: 33649524; PMCID: PMC7917958.
Rees JR, Mott LA, Barry EL, Baron JA, Bostick RM, Figueiredo JC, Bresalier RS, Robertson DJ, Peacock JL. Lifestyle and Other Factors Explain One-Half of the Variability in the Serum 25-Hydroxyvitamin D Response to Cholecalciferol Supplementation in Healthy Adults. J Nutr. 2016 Nov;146(11):2312-2324. doi: 10.3945/jn.116.236323. Epub 2016 Sep 28. PMID: 27683872; PMCID: PMC5086794.
Pourshahidi LK. Vitamin D and obesity: current perspectives and future directions. Proc Nutr Soc. 2015 May;74(2):115-24. doi: 10.1017/S0029665114001578. Epub 2014 Oct 31. PMID: 25359323.
Michael F. Holick, Neil C. Binkley, Heike A. Bischoff-Ferrari, Catherine M. Gordon, David A. Hanley, Robert P. Heaney, M. Hassan Murad, Connie M. Weaver, Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 7, 1 July 2011, Pages 1911–1930, https://doi.org/10.1210/jc.2011-0385. PMID: 21646368.
Taksler, G., Cutler, D., Giovannucci, E., & Keating, N. (2015). Vitamin D deficiency in minority populations. Public Health Nutrition, 18(3), 379-391. doi:10.1017/S1368980014000457. PMID: 25112179.
Silva MC, Furlanetto TW. Intestinal absorption of vitamin D: a systematic review. Nutr Rev. 2018 Jan 1;76(1):60-76. doi: 10.1093/nutrit/nux034. PMID: 29025082.
Nair R, Maseeh A. Vitamin D: The "sunshine" vitamin. J Pharmacol Pharmacother. 2012 Apr;3(2):118-26. doi: 10.4103/0976-500X.95506. PMID: 22629085; PMCID: PMC3356951.
Bikle DD. Vitamin D: Production, Metabolism and Mechanisms of Action. [Updated 2021 Dec 31]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK278935/
Cesari M, Incalzi RA, Zamboni V, Pahor M. Vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons. Geriatr Gerontol Int. 2011 Apr;11(2):133-42. doi: 10.1111/j.1447-0594.2010.00668.x. Epub 2010 Dec 6. PMID: 21134097; PMCID: PMC4384440.
Bogh MK, Schmedes AV, Philipsen PA, Thieden E, Wulf HC. Vitamin D production depends on ultraviolet-B dose but not on dose rate: a randomized controlled trial. Exp Dermatol. 2011 Jan;20(1):14-8. doi: 10.1111/j.1600-0625.2010.01201.x. PMID: 21158934.
Sowah D, Fan X, Dennett L, Hagtvedt R, Straube S. Vitamin D levels and deficiency with different occupations: a systematic review. BMC Public Health. 2017 Jun 22;17(1):519. doi: 10.1186/s12889-017-4436-z. PMID: 28637448; PMCID: PMC5480134.
Rizzoli R, Boonen S, Brandi ML, Bruyère O, Cooper C, Kanis JA, Kaufman JM, Ringe JD, Weryha G, Reginster JY. Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Curr Med Res Opin. 2013 Apr;29(4):305-13. doi: 10.1185/03007995.2013.766162. Epub 2013 Feb 7. PMID: 23320612.
Chalcraft JR, Cardinal LM, Wechsler PJ, Hollis BW, Gerow KG, Alexander BM, Keith JF, Larson-Meyer DE. Vitamin D Synthesis Following a Single Bout of Sun Exposure in Older and Younger Men and Women. Nutrients. 2020 Jul 27;12(8):2237. doi: 10.3390/nu12082237. PMID: 32727044; PMCID: PMC7468901.
Shaker JL, Deftos L. Calcium and Phosphate Homeostasis. [Updated 2018 Jan 19]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279023/
Garland CF, Gorham ED, Mohr SB, Garland FC. Vitamin D for cancer prevention: global perspective. Ann Epidemiol. 2009 Jul;19(7):468-83. doi: 10.1016/j.annepidem.2009.03.021. PMID: 19523595.
Boughanem H, Canudas S, Hernandez-Alonso P, Becerra-Tomás N, Babio N, Salas-Salvadó J, Macias-Gonzalez M. Vitamin D Intake and the Risk of Colorectal Cancer: An Updated Meta-Analysis and Systematic Review of Case-Control and Prospective Cohort Studies. Cancers (Basel). 2021 Jun 4;13(11):2814. doi: 10.3390/cancers13112814. PMID: 34200111; PMCID: PMC8201292.
Wang, L., et al. (2013). Vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies. European Journal of Epidemiology, 28(9), 805-813.
Moradi N, Fadaei R, Ahmadi R, Mohammad MH, Shahmohamadnejad S, Tavakoli-Yaraki M, Aghajani H, Fallah S. Role of serum MMP-9 levels and vitamin D receptor polymorphisms in the susceptibility to coronary artery disease: An association study in Iranian population. Gene. 2017 Sep 10;628:295-300. doi: 10.1016/j.gene.2017.07.060. Epub 2017 Jul 21. PMID: 28739397.
Greco D, Kocyigit D, Adorni MP, Marchi C, Ronda N, Bernini F, Gurses KM, Canpinar H, Guc D, Oguz SH, Gurlek A, Strazzella A, Simonelli S, Tokgozoglu L, Zimetti F. Vitamin D replacement ameliorates serum lipoprotein functions, adipokine profile and subclinical atherosclerosis in pre-menopausal women. Nutr Metab Cardiovasc Dis. 2018 Aug;28(8):822-829. doi: 10.1016/j.numecd.2018.04.010. Epub 2018 May 12. PMID: 29954641.
Wang L, Song Y, Manson JE, Pilz S, März W, Michaëlsson K, Lundqvist A, Jassal SK, Barrett-Connor E, Zhang C, Eaton CB, May HT, Anderson JL, Sesso HD. Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies. Circ Cardiovasc Qual Outcomes. 2012 Nov;5(6):819-29. doi: 10.1161/CIRCOUTCOMES.112.967604. Epub 2012 Nov 13. PMID: 23149428; PMCID: PMC3510675.
Jolliffe DA, Walton RT, Griffiths CJ, Martineau AR. Single nucleotide polymorphisms in the vitamin D pathway associating with circulating concentrations of vitamin D metabolites and non-skeletal health outcomes: Review of genetic association studies. J Steroid Biochem Mol Biol. 2016 Nov;164:18-29. doi: 10.1016/j.jsbmb.2015.12.007. Epub 2015 Dec 11. PMID: 26686945.
Saponaro, F., Marcocci, C. & Zucchi, R. Vitamin D status and cardiovascular outcome. J Endocrinol Invest 42, 1285–1290 (2019). https://doi.org/10.1007/s40618-019-01057-y. Epub 2019 Jun 6. PMID: 31172459.
Zhang Y, Fang F, Tang J, et al. Association between vitamin D supplementation and mortality: systematic review and meta-analysis BMJ. 2019;366:l4673. Published 2019 Aug 12. doi: /10.1136/bmj.l4673. Erratum in: BMJ. 2020 Sep 22;370:m2329. PMID: 31405892; PMCID: PMC6689821.
Dobnig H, Pilz S, Scharnagl H, et al. Independent Association of Low Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels With All-Cause and Cardiovascular Mortality. Arch Intern Med. 2008;168(12):1340–1349. doi:10.1001/archinte.168.12.1340. PMID: 18574092.
Al Mheid I, Patel R, Murrow J, Morris A, Rahman A, Fike L, Kavtaradze N, Uphoff I, Hooper C, Tangpricha V, Alexander RW, Brigham K, Quyyumi AA. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol. 2011 Jul 5;58(2):186-92. doi: 10.1016/j.jacc.2011.02.051. PMID: 21718915; PMCID: PMC3896949.
Zhang R, Li B, Gao X, Tian R, Pan Y, Jiang Y, Gu H, Wang Y, Wang Y, Liu G. Serum 25-hydroxyvitamin D and the risk of cardiovascular disease: dose-response meta-analysis of prospective studies. Am J Clin Nutr. 2017 Apr;105(4):810-819. doi: 10.3945/ajcn.116.140392. Epub 2017 Mar 1. PMID: 28251933.
Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 2007 Jun;85(6):1586-91. doi: 10.1093/ajcn/85.6.1586. Erratum in: Am J Clin Nutr. 2008 Mar;87(3):794. PMID: 17556697.
Brøndum-Jacobsen P, Benn M, Jensen GB, Nordestgaard BG. 25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies. Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2794-802. doi: 10.1161/ATVBAHA.112.248039. Epub 2012 Aug 30. PMID: 22936341.
Zhou R, Wang M, Huang H, Li W, Hu Y, Wu T. Lower Vitamin D Status Is Associated with an Increased Risk of Ischemic Stroke: A Systematic Review and Meta-Analysis. Nutrients. 2018 Feb 28;10(3):277. doi: 10.3390/nu10030277. PMID: 29495586; PMCID: PMC5872695.
Ruiz-Ballesteros AI, Meza-Meza MR, Vizmanos-Lamotte B, Parra-Rojas I, de la Cruz-Mosso U. Association of Vitamin D Metabolism Gene Polymorphisms with Autoimmunity: Evidence in Population Genetic Studies. Int J Mol Sci. 2020 Dec 17;21(24):9626. doi: 10.3390/ijms21249626. PMID: 33348854; PMCID: PMC7766382.
Ford JA, MacLennan GS, Avenell A, Bolland M, Grey A, Witham M; RECORD Trial Group. Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis. Am J Clin Nutr. 2014 Sep;100(3):746-55. doi: 10.3945/ajcn.113.082602. Epub 2014 Jul 23. PMID: 25057156.
Dibaba DT. Effect of vitamin D supplementation on serum lipid profiles: a systematic review and meta-analysis. Nutr Rev. 2019 Dec 1;77(12):890-902. doi: 10.1093/nutrit/nuz037. PMID: 31407792.
Golzarand M, Shab-Bidar S, Koochakpoor G, Speakman J R, Djafarian K. Effect of vitamin D3 supplementation on blood pressure in adults: An updated meta-analysis. Nutr Metab Cardiovasc Dis. 2016 Aug;26(8):663-73. doi: 10.1016/j.numecd.2016.04.011. Epub 2016 Apr 25. PMID: 27287826.
Vimaleswaran KS, Cavadino A, Berry DJ; LifeLines Cohort Study investigators, Jorde R, Dieffenbach AK, Lu C, Alves AC, Heerspink HJ, Tikkanen E, Eriksson J, Wong A, Mangino M, Jablonski KA, Nolte IM, Houston DK, Ahluwalia TS, van der Most PJ, Pasko D, Zgaga L, Thiering E, Vitart V, Fraser RM, Huffman JE, de Boer RA, Schöttker B, Saum KU, McCarthy MI, Dupuis J, Herzig KH, Sebert S, Pouta A, Laitinen J, Kleber ME, Navis G, Lorentzon M, Jameson K, Arden N, Cooper JA, Acharya J, Hardy R, Raitakari O, Ripatti S, Billings LK, Lahti J, Osmond C, Penninx BW, Rejnmark L, Lohman KK, Paternoster L, Stolk RP, Hernandez DG, Byberg L, Hagström E, Melhus H, Ingelsson E, Mellström D, Ljunggren O, Tzoulaki I, McLachlan S, Theodoratou E, Tiesler CM, Jula A, Navarro P, Wright AF, Polasek O; International Consortium for Blood Pressure (ICBP); Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium; Global Blood Pressure Genetics (Global BPGen) consortium; Caroline Hayward, Wilson JF, Rudan I, Salomaa V, Heinrich J, Campbell H, Price JF, Karlsson M, Lind L, Michaëlsson K, Bandinelli S, Frayling TM, Hartman CA, Sørensen TI, Kritchevsky SB, Langdahl BL, Eriksson JG, Florez JC, Spector TD, Lehtimäki T, Kuh D, Humphries SE, Cooper C, Ohlsson C, März W, de Borst MH, Kumari M, Kivimaki M, Wang TJ, Power C, Brenner H, Grimnes G, van der Harst P, Snieder H, Hingorani AD, Pilz S, Whittaker JC, Järvelin MR, Hyppönen E. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol. 2014 Sep;2(9):719-29. doi: 10.1016/S2213-8587(14)70113-5. Epub 2014 Jun 25. PMID: 24974252; PMCID: PMC4582411.
Ruiz-Ballesteros AI, Meza-Meza MR, Vizmanos-Lamotte B, Parra-Rojas I, de la Cruz-Mosso U. Association of Vitamin D Metabolism Gene Polymorphisms with Autoimmunity: Evidence in Population Genetic Studies. Int J Mol Sci. 2020 Dec 17;21(24):9626. doi: 10.3390/ijms21249626. PMID: 33348854; PMCID: PMC7766382.
Macdonald HM, Reid IR, Gamble GD, Fraser WD, Tang JC, Wood AD. 25-Hydroxyvitamin D Threshold for the Effects of Vitamin D Supplements on Bone Density: Secondary Analysis of a Randomized Controlled Trial. J Bone Miner Res. 2018 Aug;33(8):1464-1469. doi: 10.1002/jbmr.3442. Epub 2018 Jun 15. PMID: 29665087.
Vitamin D and Your Health: Breaking Old Rules, Raising New Hopes, Harvard Medical School, 13 Sept. 2021, https://www.health.harvard.edu/staying-healthy/vitamin-d-and-your-health-breaking-old-rules-raising-new-hopes.
Anglin RE, Samaan Z, Walter SD, McDonald SD. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry. 2013 Feb;202:100-7. doi: 10.1192/bjp.bp.111.106666. PMID: 23377209.
Hoogendijk WJ, Lips P, Dik MG, Deeg DJ, Beekman AT, Penninx BW. Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults. Arch Gen Psychiatry. 2008 May;65(5):508-12. doi: 10.1001/archpsyc.65.5.508. PMID: 18458202.
Sue Penckofer, Mary Byrn, William Adams, Mary Ann Emanuele, Patricia Mumby, Joanne Kouba, Diane E. Wallis, "Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes", Journal of Diabetes Research, vol. 2017, Article ID 8232863, 11 pages, 2017. https://doi.org/10.1155/2017/8232863. Epub 2017 Sep 7. PMID: 29082262; PMCID: PMC5610883.
Martineau, A. R., et al. (2017). Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. British Medical Journal, 356, i6583. doi: 10.1136/bmj.i6583. PMID: 28202713; PMCID: PMC5310969.
Shaffer JA, Edmondson D, Wasson LT, Falzon L, Homma K, Ezeokoli N, Li P, Davidson KW. Vitamin D supplementation for depressive symptoms: a systematic review and meta-analysis of randomized controlled trials. Psychosom Med. 2014 Apr;76(3):190-6. doi: 10.1097/PSY.0000000000000044. PMID: 24632894; PMCID: PMC4008710.
Martens PJ, Gysemans C, Verstuyf A, Mathieu AC. Vitamin D's Effect on Immune Function. Nutrients. 2020 Apr 28;12(5):1248. doi: 10.3390/nu12051248. PMID: 32353972; PMCID: PMC7281985.
Sassi F, Tamone C, D'Amelio P. Vitamin D: Nutrient, Hormone, and Immunomodulator. Nutrients. 2018 Nov 3;10(11):1656. doi: 10.3390/nu10111656. PMID: 30400332; PMCID: PMC6266123.
Giovannucci, E., et al. (2006). Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. Journal of the National Cancer Institute, 98(7), 451-459. doi: 10.1093/jnci/djj101. PMID: 16595781.
Chen, J., et al. (2011). Vitamin D and risk of breast cancer: a meta-analysis of prospective studies. American Journal of Clinical Nutrition, 93(2), 240-246.
Yin L, Ordóñez-Mena JM, Chen T, Schöttker B, Arndt V, Brenner H. Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: a systematic review and meta-analysis. Prev Med. 2013 Dec;57(6):753-64. doi: 10.1016/j.ypmed.2013.08.026. Epub 2013 Sep 10. PMID: 24036014.
Okereke OI, Singh A. The role of vitamin D in the prevention of late-life depression. J Affect Disord. 2016 Jul 1;198:1-14. doi: 10.1016/j.jad.2016.03.022. Epub 2016 Mar 9. PMID: 26998791; PMCID: PMC4844780.
Menon V, Kar SK, Suthar N, Nebhinani N. Vitamin D and Depression: A Critical Appraisal of the Evidence and Future Directions. Indian J Psychol Med. 2020 Jan 6;42(1):11-21. doi: 10.4103/IJPSYM.IJPSYM_160_19. PMID: 31997861; PMCID: PMC6970300.
Ceolin G, Antunes LDC, Moretti M, Rieger DK, Moreira JD. VITAMIN D AND DEPRESSION IN OLDER ADULTS: LESSONS LEARNED FROM OBSERVATIONAL AND CLINICAL STUDIES. Nutr Res Rev. 2022 Jan 13:1-63. doi: 10.1017/S0954422422000026. Epub ahead of print. PMID: 35022097.
Spedding S. Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients. 2014 Apr 11;6(4):1501-18. doi: 10.3390/nu6041501. PMID: 24732019; PMCID: PMC4011048.
Vellekkatt F, Menon V. Efficacy of vitamin D supplementation in major depression: A meta-analysis of randomized controlled trials. J Postgrad Med. 2019 Apr-Jun;65(2):74-80. doi: 10.4103/jpgm.JPGM_571_17. PMID: 29943744; PMCID: PMC6515787.
Guzek D, Kołota A, Lachowicz K, Skolmowska D, Stachoń M, Głąbska D. Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review. Nutrients. 2021 Oct 20;13(11):3678. doi: 10.3390/nu13113678. PMID: 34835934; PMCID: PMC8625262.
Han J, Guo X, Yu X, Liu S, Cui X, Zhang B, Liang H. 25-Hydroxyvitamin D and Total Cancer Incidence and Mortality: A Meta-Analysis of Prospective Cohort Studies. Nutrients. 2019 Sep 26;11(10):2295. doi: 10.3390/nu11102295. PMID: 31561503; PMCID: PMC6835972.
Cheng YC, Huang YC, Huang WL. The effect of vitamin D supplement on negative emotions: A systematic review and meta-analysis. Depress Anxiety. 2020 Jun;37(6):549-564. doi: 10.1002/da.23025. Epub 2020 May 4. PMID: 32365423.
Bičíková M, Dušková M, Vítků J, Kalvachová B, Řípová D, Mohr P, Stárka L. Vitamin D in anxiety and affective disorders. Physiol Res. 2015;64(Suppl 2):S101-3. doi: 10.33549/physiolres.933082. PMID: 26680471.
Fallah M, Askari G, Asemi Z. Is Vitamin D Status Associated with Depression, Anxiety and Sleep Quality in Pregnancy: A Systematic Review. Adv Biomed Res. 2020 Jul 27;9:32. doi: 10.4103/abr.abr_188_19. PMID: 33072644; PMCID: PMC7532825.
Keum N, Giovannucci E. Vitamin D supplements and cancer incidence and mortality: a meta-analysis. Br J Cancer. 2014 Aug 26;111(5):976-80. doi: 10.1038/bjc.2014.294. Epub 2014 Jun 10. PMID: 24918818; PMCID: PMC4150260.
Keum N, Lee DH, Greenwood DC, Manson JE, Giovannucci E. Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials. Ann Oncol. 2019 May 1;30(5):733-743. doi: 10.1093/annonc/mdz059. PMID: 30796437; PMCID: PMC6821324.
D'Souza RS, Lin G, Oh T, Vincent A, Orhurhu V, Jiang L, Mauck WD, Qu W. Fibromyalgia Symptom Severity and Psychosocial Outcomes in Fibromyalgia Patients with Hypovitaminosis D: A Prospective Questionnaire Study. Pain Med. 2020 Dec 25;21(12):3470-3478. doi: 10.1093/pm/pnz377. PMID: 32022867.
O'Brien KM, Sandler DP, Taylor JA, Weinberg CR. Serum Vitamin D and Risk of Breast Cancer within Five Years. Environ Health Perspect. 2017 Jul 6;125(7):077004. doi: 10.1289/EHP943. PMID: 28728134; PMCID: PMC5744694.
Yao S, Kwan ML, Ergas IJ, Roh JM, Cheng TD, Hong CC, McCann SE, Tang L, Davis W, Liu S, Quesenberry CP Jr, Lee MM, Ambrosone CB, Kushi LH. Association of Serum Level of Vitamin D at Diagnosis With Breast Cancer Survival: A Case-Cohort Analysis in the Pathways Study. JAMA Oncol. 2017 Mar 1;3(3):351-357. doi: 10.1001/jamaoncol.2016.4188. PMID: 27832250; PMCID: PMC5473032.
McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang M, Cook NR, Eliassen AH, Zeleniuch-Jacquotte A, Agnoli C, Albanes D, Barnett MJ, Buring JE, Campbell PT, Clendenen TV, Freedman ND, Gapstur SM, Giovannucci EL, Goodman GG, Haiman CA, Ho GYF, Horst RL, Hou T, Huang WY, Jenab M, Jones ME, Joshu CE, Krogh V, Lee IM, Lee JE, Männistö S, Le Marchand L, Mondul AM, Neuhouser ML, Platz EA, Purdue MP, Riboli E, Robsahm TE, Rohan TE, Sasazuki S, Schoemaker MJ, Sieri S, Stampfer MJ, Swerdlow AJ, Thomson CA, Tretli S, Tsugane S, Ursin G, Visvanathan K, White KK, Wu K, Yaun SS, Zhang X, Willett WC, Gail MH, Ziegler RG, Smith-Warner SA. Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts. J Natl Cancer Inst. 2019 Feb 1;111(2):158-169. doi: 10.1093/jnci/djy087. PMID: 29912394; PMCID: PMC6376911.
Xu Y, Shao X, Yao Y, Xu L, Chang L, Jiang Z, Lin Z. Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk: new findings from an updated meta-analysis. J Cancer Res Clin Oncol. 2014 Sep;140(9):1465-77. doi: 10.1007/s00432-014-1706-3. Epub 2014 May 17. PMID: 24838848.
Heath AK, Hodge AM, Ebeling PR, Eyles DW, Kvaskoff D, Buchanan DD, Giles GG, Williamson EJ, English DR. Circulating 25-Hydroxyvitamin D Concentration and Risk of Breast, Prostate, and Colorectal Cancers: The Melbourne Collaborative Cohort Study. Cancer Epidemiol Biomarkers Prev. 2019 May;28(5):900-908. doi: 10.1158/1055-9965.EPI-18-1155. Epub 2019 Mar 6. PMID: 30842127.
Nair-Shalliker V, Bang A, Egger S, Clements M, Gardiner RA, Kricker A, Seibel MJ, Chambers SK, Kimlin MG, Armstrong BK, Smith DP. Post-treatment levels of plasma 25- and 1,25-dihydroxy vitamin D and mortality in men with aggressive prostate cancer. Sci Rep. 2020 May 8;10(1):7736. doi: 10.1038/s41598-020-62182-w. PMID: 32385370; PMCID: PMC7210996.
Song ZY, Yao Q, Zhuo Z, Ma Z, Chen G. Circulating vitamin D level and mortality in prostate cancer patients: a dose-response meta-analysis. Endocr Connect. 2018 Dec 1;7(12):R294-R303. doi: 10.1530/EC-18-0283. PMID: 30352424; PMCID: PMC6240137.
Deng X, Song Y, Manson JE, Signorello LB, Zhang SM, Shrubsole MJ, Ness RM, Seidner DL, Dai Q. Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III. BMC Med. 2013 Aug 27;11:187. doi: 10.1186/1741-7015-11-187. PMID: 23981518; PMCID: PMC3765911.
Kidd PM. Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy. Altern Med Rev. 2010 Sep;15(3):199-222. PMID: 21155624.
Zittermann, A. Magnesium deficit - overlooked cause of low vitamin D status?. BMC Med 11, 229 (2013). https://doi.org/10.1186/1741-7015-11-229.
Shahsavani, Z., Asadi, A., Shamshirgardi, E., Akbarzadeh, M. (2021). 'Vitamin D, Magnesium and Their Interactions: A Review', International Journal of Nutrition Sciences, 6(3), pp. 113-118. doi: 10.30476/ijns.2021.91766.1144.
Borradale, D., & Kimlin, M. (2009). Vitamin D in health and disease: An insight into traditional functions and new roles for the ‘sunshine vitamin’. Nutrition Research Reviews, 22(2), 118-136. doi:10.1017/S0954422409990102.
Zittermann, A. (2003). Vitamin D in preventive medicine: Are we ignoring the evidence? British Journal of Nutrition, 89(5), 552-572. doi:10.1079/BJN2003837.
Zittermann A. Magnesium deficit ? overlooked cause of low vitamin D status? BMC Med. 2013 Oct 24;11:229. doi: 10.1186/1741-7015-11-229. PMID: 24228832; PMCID: PMC3854088.
Uwitonze AM, Razzaque MS. Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc. 2018 Mar 1;118(3):181-189. doi: 10.7556/jaoa.2018.037. PMID: 29480918.
Jat KR. Vitamin D deficiency and lower respiratory tract infections in children: a systematic review and meta-analysis of observational studies. Trop Doct. 2017 Jan;47(1):77-84. doi: 10.1177/0049475516644141. Epub 2016 May 13. PMID: 27178217.
Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. 2010 Aug;85(8):752-7; quiz 757-8. doi: 10.4065/mcp.2010.0138. PMID: 20675513; PMCID: PMC2912737.
Pletz MW, Terkamp C, Schumacher U, Rohde G, Schütte H, Welte T, Bals R; CAPNETZ-Study Group. Vitamin D deficiency in community-acquired pneumonia: low levels of 1,25(OH)2 D are associated with disease severity. Respir Res. 2014 Apr 27;15(1):53. doi: 10.1186/1465-9921-15-53. PMID: 24766747; PMCID: PMC4046524.
Bergman P, Norlin AC, Hansen S, Björkhem-Bergman L. Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo-controlled trial. BMC Res Notes. 2015 Aug 30;8:391. doi: 10.1186/s13104-015-1378-3. PMID: 26319134; PMCID: PMC4553208.
Bradley R, Schloss J, Brown D, Celis D, Finnell J, Hedo R, Honcharov V, Pantuso T, Peña H, Lauche R, Steel A. The effects of vitamin D on acute viral respiratory infections: A rapid review. Adv Integr Med. 2020 Dec;7(4):192-202. doi: 10.1016/j.aimed.2020.07.011. Epub 2020 Aug 3. PMID: 32837896; PMCID: PMC7397989.
Kidd PM. Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy. Altern Med Rev. 2010 Sep;15(3):199-222. PMID: 21155624.
Mernitz H, Smith DE, Wood RJ, Russell RM, Wang XD. Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity. Int J Cancer. 2007 Apr 1;120(7):1402-9. doi: 10.1002/ijc.22462. PMID: 17205520.
Kassi E, Adamopoulos C, Basdra EK, Papavassiliou AG. Role of vitamin D in atherosclerosis. Circulation. 2013 Dec 3;128(23):2517-31. doi: 10.1161/CIRCULATIONAHA.113.002654. PMID: 24297817.
Pennisi M, Malaguarnera G, Di Bartolo G, Lanza G, Bella R, Chisari EM, Cauli O, Vicari E, Malaguarnera M. Decrease in Serum Vitamin D Level of Older Patients with Fatigue. Nutrients. 2019 Oct 20;11(10):2531. doi: 10.3390/nu11102531. PMID: 31635199; PMCID: PMC6836014.
Al-Shawwa B, Ehsan Z, Ingram DG. Vitamin D and sleep in children. J Clin Sleep Med. 2020 Jul 15;16(7):1119-1123. doi: 10.5664/jcsm.8440. PMID: 32672533; PMCID: PMC7954071.
Masoudi Alavi N, Madani M, Sadat Z, Haddad Kashani H, Reza Sharif M. Fatigue and Vitamin D Status in Iranian Female Nurses. Glob J Health Sci. 2015 Nov 17;8(6):196-202. doi: 10.5539/gjhs.v8n6p196. PMID: 26755458; PMCID: PMC4954906.
Njoku K, Iveson E. Does Vitamin D Deficiency Predispose to Post Stroke Fatigue? Ir Med J. 2020 Feb 13;113(2):23. PMID: 32338839.
Nowak A, Boesch L, Andres E, Battegay E, Hornemann T, Schmid C, Bischoff-Ferrari HA, Suter PM, Krayenbuehl PA. Effect of vitamin D3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial. Medicine (Baltimore). 2016 Dec;95(52):e5353. doi: 10.1097/MD.0000000000005353. Erratum in: Medicine (Baltimore). 2017 Jan 20;96(3):e6038. PMID: 28033244; PMCID: PMC5207540.
Bergman P, Norlin AC, Hansen S, Björkhem-Bergman L. Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo-controlled trial. BMC Res Notes. 2015 Aug 30;8:391. doi: 10.1186/s13104-015-1378-3. PMID: 26319134; PMCID: PMC4553208.
Gil Á, Plaza-Diaz J, Mesa MD. Vitamin D: Classic and Novel Actions. Ann Nutr Metab. 2018;72(2):87-95. doi: 10.1159/000486536. Epub 2018 Jan 18. PMID: 29346788.
Aspray TJ, Hill TR. Osteoporosis and the Ageing Skeleton. Subcell Biochem. 2019;91:453-476. doi: 10.1007/978-981-13-3681-2_16. PMID: 30888662.
Bener A, Saleh NM. Low vitamin D, and bone mineral density with depressive symptoms burden in menopausal and postmenopausal women. J Midlife Health. 2015 Jul-Sep;6(3):108-14. doi: 10.4103/0976-7800.165590. PMID: 26538987; PMCID: PMC4604669.
Weaver CM, Alexander DD, Boushey CJ, Dawson-Hughes B, Lappe JM, LeBoff MS, Liu S, Looker AC, Wallace TC, Wang DD. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int. 2016 Jan;27(1):367-76. doi: 10.1007/s00198-015-3386-5. Epub 2015 Oct 28. Erratum in: Osteoporos Int. 2016 Aug;27(8):2643-6. PMID: 26510847; PMCID: PMC4715837.
Olmedo Martín RV, González Molero I, Olveira Fuster G, Amo Trillo V, Jiménez Pérez M. Vitamin D deficiency in outpatients with inflammatory bowel disease: prevalence and association with clinical-biological activity. Rev Esp Enferm Dig. 2019 Jan;111(1):46-54. doi: 10.17235/reed.2018.5714/2018. PMID: 30284908.
Chahal-Kummen M, Salte OBK, Hewitt S, Blom-Høgestøl IK, Risstad H, Kristinsson J, Mala T. Health benefits and risks during 10 years after Roux-en-Y gastric bypass. Surg Endosc. 2020 Dec;34(12):5368-5376. doi: 10.1007/s00464-019-07328-2. Epub 2020 Jan 28. PMID: 31993812; PMCID: PMC7644522.
Fletcher J, Cooper SC, Ghosh S, Hewison M. The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management. Nutrients. 2019 May 7;11(5):1019. doi: 10.3390/nu11051019. PMID: 31067701; PMCID: PMC6566188.
Limketkai BN, Mullin GE, Limsui D, Parian AM. Role of Vitamin D in Inflammatory Bowel Disease. Nutr Clin Pract. 2017 Jun;32(3):337-345. doi: 10.1177/0884533616674492. Epub 2016 Oct 21. PMID: 28537516.
Timms, P.M., Mannan, N., Hitman, G.A., Noonan, K., Mills, P.G., Syndercombe‐Court, D., Aganna, E., Price, C.P. and Boucher, B.J., 2002. Circulating MMP9, vitamin D and variation in the TIMP‐1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders?. Qjm, 95(12), pp.787-796. https://doi.org/10.1093/qjmed/95.12.787.
Wakeman M. A Literature Review of the Potential Impact of Medication on Vitamin D Status. Risk Manag Healthc Policy. 2021 Aug 14;14:3357-3381. doi: 10.2147/RMHP.S316897. PMID: 34421316; PMCID: PMC8373308.
Ghai B, Bansal D, Kapil G, Kanukula R, Lavudiya S, Sachdeva N. High Prevalence of Hypovitaminosis D in Indian Chronic Low Back Patients. Pain Physician. 2015 Sep-Oct;18(5):E853-62. PMID: 26431139.
Bansal D, Boya CS, Vatte R, Ghai B. High Prevalence of Hypovitaminosis D in Patients with Low Back Pain: Evidence from Meta-Analysis. Pain Physician. 2018 Jul;21(4):E389-E399. PMID: 30045605.
Gokcek E, Kaydu A. Assessment of Relationship between Vitamin D Deficiency and Pain Severity in Patients with Low Back Pain: A Retrospective, Observational Study. Anesth Essays Res. 2018 Jul-Sep;12(3):680-684. doi: 10.4103/aer.AER_96_18. Erratum in: Anesth Essays Res. 2018 Oct-Dec;12(4):970. PMID: 30283175; PMCID: PMC6157211.
Zadro J, Shirley D, Ferreira M, Carvalho-Silva AP, Lamb SE, Cooper C, Ferreira PH. Mapping the Association between Vitamin D and Low Back Pain: A Systematic Review and Meta-Analysis of Observational Studies. Pain Physician. 2017 Nov;20(7):611-640. PMID: 29149142.
Wu Z, Malihi Z, Stewart AW, Lawes CM, Scragg R. The association between vitamin D concentration and pain: a systematic review and meta-analysis. Public Health Nutr. 2018 Aug;21(11):2022-2037. doi: 10.1017/S1368980018000551. Epub 2018 Mar 21. PMID: 29559013.
Ding J, Kwan P, Ma Z, Iwashina T, Wang J, Shankowsky HA, Tredget EE. Synergistic effect of vitamin D and low concentration of transforming growth factor beta 1, a potential role in dermal wound healing. Burns. 2016 Sep;42(6):1277-86. doi: 10.1016/j.burns.2016.03.009. Epub 2016 May 22. PMID: 27222384.
Fakheran O, Khodadadi-Bohlouli Z, Khademi A. Effect of vitamin D level on periodontal treatment outcomes: a systematic review. Gen Dent. 2019 Mar-Apr;67(2):64-67. PMID: 30875309.
Tiwari S, Pratyush DD, Gupta SK, Singh SK. Vitamin D deficiency is associated with inflammatory cytokine concentrations in patients with diabetic foot infection. Br J Nutr. 2014 Dec 28;112(12):1938-43. doi: 10.1017/S0007114514003018. Epub 2014 Oct 21. PMID: 25331710.
Razzaghi R, Pourbagheri H, Momen-Heravi M, Bahmani F, Shadi J, Soleimani Z, Asemi Z. The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial. J Diabetes Complications. 2017 Apr;31(4):766-772. doi: 10.1016/j.jdiacomp.2016.06.017. Epub 2016 Jun 23. PMID: 27363929.
Asghar F, Shamim N, Farooque U, Sheikh H, Aqeel R. Telogen Effluvium: A Review of the Literature. Cureus. 2020 May 27;12(5):e8320. doi: 10.7759/cureus.8320. PMID: 32607303; PMCID: PMC7320655.
Guo EL, Katta R. Diet and hair loss: effects of nutrient deficiency and supplement use. Dermatol Pract Concept. 2017 Jan 31;7(1):1-10. doi: 10.5826/dpc.0701a01. PMID: 28243487; PMCID: PMC5315033.
Lin RL, Garibyan L, Kimball AB, Drake LA. Systemic causes of hair loss. Ann Med. 2016 Sep;48(6):393-402. doi: 10.1080/07853890.2016.1180426. Epub 2016 May 5. PMID: 27145919.
Lin X, Meng X, Song Z. Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy. Am J Transl Res. 2019 Sep 15;11(9):5285-5300. PMID: 31632510; PMCID: PMC6789271.
Liu Y, Li J, Liang G, Cheng C, Li Y, Wu X. Association of Alopecia Areata with Vitamin D and Calcium Levels: A Systematic Review and Meta-analysis. Dermatol Ther (Heidelb). 2020 Oct;10(5):967-983. doi: 10.1007/s13555-020-00433-4. Epub 2020 Aug 9. PMID: 32772238; PMCID: PMC7477029.
Gade VKV, Mony A, Munisamy M, Chandrashekar L, Rajappa M. An investigation of vitamin D status in alopecia areata. Clin Exp Med. 2018 Nov;18(4):577-584. doi: 10.1007/s10238-018-0511-8. Epub 2018 Jun 4. PMID: 29869122.
Aksu Cerman A, Sarikaya Solak S, Kivanc Altunay I. Vitamin D deficiency in alopecia areata. Br J Dermatol. 2014 Jun;170(6):1299-304. doi: 10.1111/bjd.12980. PMID: 24655364.
Cleveland Clinic. “Vitamin D Deficiency: Causes, Symptoms & Treatment,” n.d. https://my.clevelandclinic.org/health/diseases/15050-vitamin-d-vitamin-d-deficiency.
Pfiffner, Morgan M and Examine.com. “Vitamin D.” Examine, September 28, 2022. https://examine.com/supplements/vitamin-d/.
Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A. The Role of Vitamins and Minerals in Hair Loss: A Review. Dermatol Ther (Heidelb). 2019 Mar;9(1):51-70. doi: 10.1007/s13555-018-0278-6. Epub 2018 Dec 13. PMID: 30547302; PMCID: PMC6380979.
Çerman AA, Solak SS, Altunay İ, Küçükünal NA. Topical Calcipotriol Therapy for Mild-to-Moderate Alopecia Areata: A Retrospective Study. J Drugs Dermatol. 2015 Jun;14(6):616-20. PMID: 26091388.
Saini K, Mysore V. Role of vitamin D in hair loss: A short review. J Cosmet Dermatol. 2021 Nov;20(11):3407-3414. doi: 10.1111/jocd.14421. Epub 2021 Sep 22. PMID: 34553483.
Helde-Frankling M, Björkhem-Bergman L. Vitamin D in Pain Management. Int J Mol Sci. 2017 Oct 18;18(10):2170. doi: 10.3390/ijms18102170. PMID: 29057787; PMCID: PMC5666851.

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